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    The #1 Gastroenterologist-Recommended

    Looking for the dietary management of lBS, UC or pouchitis? Or seeking support
    for regularity and digestion?* No worries, we can help!
    TVSL#3®, ProVoice® Surveys

    Multi-Strain Probiotics Brand

Serious Gut Issues Or Everyday Wellness?

Whatever your need, our potent probiotics are scientifically formulated to support your digestive well-being:

  • VSL#3® is a probiotic medical food intended for the dietary management of IBS, UC and pouchitis.

VSL#3®  Capsules

High-potency probiotic medical food capsules scientifically formulated for the dietary management of IBS and ulcerative colitis.

Probiotic Medical Food

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We Are Pros In Probiotics

We've been making powerful, multi-strain probiotics for over twenty years, and our products are available in over 40 countries. Our experience has helped us gain the expertise needed to provide you with the right gut health solutions. Learn more about what makes our products special.

Potency, Guaranteed

Eight-Strain Diversity

Shipped To Survive, Made To Thrive

Highly Researched

Potency, Guaranteed

VSL#3® offers some of the highest-potency probiotics available, ranging from 112.5 billion to 900 billion CFU per serving.

While some probiotic brands quote their potency based on the bacteria present at the date of manufacture, we quote the CFU count of our products at expiration if stored under recommended conditions. This means you get more of what you pay for.

Eight-Strain Diversity

Shipped To Survive, Made To Thrive

Highly Researched

Nut-Free

Vegan

Dairy-Free

Soy-Free

Gluten-Free

Non-GMO

Nut-Free

Vegan

Dairy-Free

Soy-Free

Gluten-Free

Non-GMO

The Importance of Potency

Colony-forming units, or CFU, are a unit of measurement used to determine the number of bacterial cells in probiotics. Adequate CFU counts are essential for probiotics to work.

VSL#3® offers some of the highest-potency options available, ranging from 112.5 billion to 900 billion CFU per serving. 

In addition, while some probiotic brands quote their potency based on the bacteria present at the date of manufacture, we guarantee the labeled CFU count of our products at expiration if stored under recommended conditions. This means you get more of what you pay for.

The Importance of Strain Diversity

Research suggests that biodiversity in the gut microbiota can symbiotically promote overall gut health and make the microbiota more capable and resilient, which, as mentioned above, can support multiple health systems.

VSL#3® contains eight complementary strains from three different genera. It has been shown to manage microbial imbalances associated with certain digestive conditions. 

The Importance of CFU Survival

For probiotics to be effective they need to reach the intestines in sufficient quantities. Once there, they can adhere to the intestinal walls to colonize and interact effectively with your microbiota. This interaction allows them to compete with bad bacteria for adhesion sites and nutrients, produce antimicrobial substances, and modulate the immune system by enhancing gut barrier function and reducing inflammation.

VSL#3®

VSL#3® is optimized to reach the intestinal tract in two unique ways:

  1. We use a “cold chain” supply chain, which is a temperature-controlled supply chain comprising refrigerated production, storage, and distribution facilities. We then ship VSL#3® to you in thermally lined, refrigerated shipping boxes. These measures ensure that our bacteria arrive alive and ready to colonize your gut. 
  2. VSL#3® is formulated to survive the harsh conditions of the gastrointestinal (GI) tract. In fact, it has been shown to have a 99% survivability rate after 120 minutes in a model of synthetic stomach acid - significantly higher than many of the other products tested1.

The Importance of Research

Research helps identify and verify the specific health benefits associated with different probiotic strains and formulations, to help ensure that consumers receive products that are both safe and effective. 

We are committed to helping the scientific and medical communities better understand the effects of probiotics on the microbiota and overall health. VSL#3® has been the subject of more than 40 scientific publications in the last five years alone. Researchers turn to VSL#3® because of its potency, eight-strain diversity, refrigerated bacteria, and overall quality. 

  • "l recommend VSL#3® for maintenance of a healthy gut microbiome."

    Dr. George Barret MD

    Founder and Chief of Gastroenterology Beth lsrael Deaconess Hospital -Milton, MA

  • "The best product for lBD.I strongly recommend VSL#3® "



    Dr. Victor Gallo
    Garden City Colon and Rectal Surgery Practice - Garden City, NY

  • "|'ve had great successin using VSL#3® post colonoscopy, and especially so in my lBS and UC patients."


    Dr. William Andy Shaver MD Gastroenterologist Lubbock, TX

    VSL® Probiotics vs The Other Guys

    Probiotic Medical Food Brands

    VSL#3®**

    Visbiome®**

    CFU per Serving (billions)

    112.5-900 

    112.5-900 

    # of Strains

    8

    8

    Refrigerated

    yes

    yes

    Medical Food

    yes

    yes

    Dairy Free

    yes

    no

    The #1 gastroenterologist-recommended multi-strain probiotics brand†

    yes

    no

    Real Reviews, Real Results

    • Finally lBS relief!

      These probiotics are amazing! l suffer with lBS and these really help me. l've tried many brands of probiotics but these work and are worth every penny!

      Verified Buyer: VSL#3®

    • Great product!

      "Love VSL! significantly reduced symptoms of bloating, cramping and stool consistency.“

      Verified Buyer: VSL#3®

    • Good Gut, Almighty!

      "This the best probiotic on the market.It has the highest bacteria count. lt helps me a great deal with my lBS.”

      Verified Buyer: VSL#3®

    • This stuff

      "This stuff has been an absolute game-changer in managing my UC.G_d bless VSL#3."

      Verified Buyer: VSL#3®

    • The only probiotic that helps with my lBS

      "l've tried every other probiotic andnone of them works but VSL3.”


      Verified Buyer: VSL#3®

    • Good stuff!

      "l have used for years and love this stuff. lt helps control my pouchitis."


      Verified Buyer: VSL#3®

      VSL#3® is a FODMAP Friendly Approved Product

      The FODMAP Friendly lgo means our product has been independently tested and certifed low in fermentable carbs (fFoDMAPs) that can cause digestive discomfort. If you have lBS or a sensitive gut, this certification helps you choose products that are less likely to trigger symptoms like bloating, gas, or stomach pain.

        ABOUT VSL

        Do VSL® products contain milk or dairy?

        VSL®products are milk-free and dairy-free!

        How should I store my VSL® products?

        VSL#3®should be kept refrigerated; however, it can be stored at room temperature (77°F) for up to two weeks without affecting the labeled potency.

        What To Expect When First Starting VSL®?

        Is this your first time taking probiotics? Some people may notice mild digestive changes like occasional bloating when they start taking probiotics. This is normal. It's like introducing new guests to your gut party—things might get a bit lively as your microbiome adjusts. But fear not! These side effects typically subside within a few days or weeks.

        And here's the exciting part: for those dealing with the discomforts associated with digestive issues, probiotics like VSL#3® and VSL4™ Gut offer hope. With their beneficial bacteria, our products are here to help you find digestive relief and support your gut health goals.

        Note it may take up to one month for the colonization of the gut to become optimally balanced.

        VSL#3® Symptom Relief

        In a March 2022 suney of gastroenterolgist, 93% of respondent stated that their patients were satisfied with VSL#3® .The folowing were the top symptam improvements observed by the doctors:
        Less bloating
        Overall symptom improvement
        Less pain
        Better stool frequency, less diarrhea

        VSL#3®, IBS and the Low FODMAP Diet

        Ever heard of FODMAPs? FODMAP stands for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols. Essentially, these are types of carbs that your small intestine finds a bit tricky to absorb. Foods that contain FODMAPs include dairy (milk, ice cream, yogurt, more), many fruits (apples, bananas, peaches, watermelon, cherries, coconut, pineapple, raspberries, blueberries, cranberries, avocado, more), vegetables (broccoli, eggplant, sweet corn, sweet potato, green beans, cabbage, celery, chilis, onions, mushrooms, more), and grains (wheat, barley, rye and more).

        For some folks, munching on foods rich in FODMAPs can lead to uncomfortable digestive issues like cramping, diarrhea, constipation, bloating, and gas. These symptoms often go hand-in-hand with conditions like IBS.

        A low FODMAP diet is a popular approach to managing IBS symptoms; however, it is restrictive and eliminates some staple foods. As a result, some on the diet may be at risk of reduced intake of key nutrients like fiber, iron, zinc, B and D vitamins and natural antioxidants. The long-term impact of such a diet is poorly understood, and the drastic reduction of FODMAP consumption could have consequences on your metabolism and intestinal microbiota2. In addition, adherence to a LOW FODMAP diet can be difficult. But, there is an alternative!